Seth Rogen and Rose Byrne weigh in on ‘When Harry Met Sally’ debate of ‘Platonic’ friendships

Can men and women be friends? 1989’s “ When Harry Met Sally ” said no, but Rose Byrne and Seth Rogen disagree.

The pair co-star in the new Apple TV+ series “ Platonic,” debuting Wednesday, about longtime best friends who, as the title suggests, are just that. In fact, the actors had conversations early on to make sure the characters never cross a line.

“I honestly don’t like things about infidelity,” Rogen said in a recent interview. “I just don’t like it. That was something that I was like so clear (on) and something we talked about a lot… ’How do we signal to the audience, ‘that’s not a thing we have to worry about’? They can enjoy the show, laugh and not have this nagging thing in the back of their heads of like, ‘Is she going to cheat on her husband with this guy?’”

Both Byrne and Rogen, who are each married, say they have longtime friends of the opposite sex.

“I have a lot of friendships with women that I’ve had for decades and decades and decades,” he said. “I still am on a text chain with two girls who I went to an elementary school and summer camp with.”

Byrne recalls a “very intense” friendship she had with a male years ago when they were both struggling actors. The two were also roommates and leaned on each other, as friends do. What brought them comfort was a hot topic among outsiders.